




THE NEW QUALITY PARAMETER IN HEMORRHOID TREATMENT
It is a food supplement formulated with patented phytocomplexes and high-quality plant extracts standardized title and designed to promote the correct functionality of venous and lymphatic circulation and reduce the symptoms associated with hemorrhoids, such as itching, burning, pain, Swelling, bleeding, constipation, heaviness, and discomfort.
Acute hemorrhoidal syndrome affects approximately 50%of the population, severely impacting their quality of life.5% of patients experience signs and symptoms of hemorrhoidal disease, both acute and chronic, of varying degrees.
SCIENTIFIC STUDY
PHENOLIC COMPOSITION OF THE HYDROPHILIC EXTRACT OF MANNA FROM FRAXINUS ANGUSTIFOLIA VAHL SICILIANA AND ITS REDUCING, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY IN VITRO
Pharmacokinetic Profile of µSMIN Plus™, a new Micronized Diosmin Formulation, after Oral Administration in Rats
ANTI-INFLAMMATORY PROPERTIES OF A PATENTED BROMELAIN EXTRACT (BROMEYAL™) AFTER SIMULATED IN VITRO GASTROINTESTINAL DIGESTION
How it Works
The product acts comprehensively and synergistically on intestinal and anal well-being thanks to an advanced formulation supported by three patents, the result of research and innovation, designed to provide effective support for the condition and simplify treatment. By drawing water into the intestinal lumen, Ash Manna helps soften stools and thereby promotes intestinal regularity. This helps reduce straining during bowel movements, one of the main causes of discomfort and irritation in the anal area.
The presence of coumarins and antioxidants in the Ash Manna phytocomplex gives the product a decongestant and tissue-repairing action, helping to promote fluid drainage and support the body’s natural tissue repair processes, thereby contributing to the reduction of local swelling and discomfort.

Thanks to the prebiotic and eubiotic action of Ash Manna, Physiomanna Procto helps maintain the optimal balance of the intestinal microbiota, improving the intestinal environment and promoting the absorption of active ingredients and the overall effectiveness of the formulation.
The formula is further enhanced by the presence of Microsmin® SG PLUS, a new and more effective source of diosmin, a flavonoid known for its role in supporting venous microcirculation and the function of the hemorrhoidal plexus. Thanks to an innovative mechanical process of ultrafine micronization and granulation, together with a specific treatment that promotes the conversion of diosmin into its more soluble active metabolite, diosmetin, Microsmin® SG PLUS has a significantly higher bioavailability than conventional diosmin, up to 9 times greater at the same dose. This enables more efficient absorption and improved efficacy of the formulation, particularly evident in the rapidity of results and the reduced need for repeated treatment administration. In addition, its patented technology improves palatability, allowing it to be delivered in convenient soluble sachets.

COMPARATIVE BIOAVAILABILITY OF TWO FORMULATIONS OF DIOSMIN AFTER ORAL ADMINISTRATION TO HEALTHY VOLUNTEERS.
The presence of Melilot (dry extract standardized to 20% coumarin) contributes to the proper function of the venous and lymphatic circulation, particularly at the level of the hemorrhoidal plexus, while also promoting the drainage of body fluids.
Pineapple (dry extract) supports digestive function, microcirculatory function, and fluid drainage, contributing to the overall well-being of the affected area.
The formulation is completed by Bromeyal®, an innovative, highly concentrated form of bromelain that is effective even when taken with food. This enzyme is known for its anti-edematous and anti-inflammatory properties and is widely used to help reduce swelling and discomfort associated with hemorrhoidal symptoms.
Further supporting the anti-inflammatory action of Physiomanna Procto are the bioactive compounds naturally present in the Ash Manna phytocomplex, such as tyrosol, verbascoside, and gallic acid. These compounds provide important anti-inflammatory effects, helping to counteract irritation and promote comfort in the anal area.
Physiomanna Procto is a soluble powdered food supplement packaged in convenient single-dose sachets to be dissolved in a glass containing 200 ml of water. The sachets offer excellent palatability, are easy to take, and are ideal for use away from home, making daily use simple and convenient.
Thanks to its combination of natural ingredients, microcirculation-supporting active compounds, and patented high-bioavailability technologies, Physiomanna Procto represents an innovative and targeted support for intestinal well-being and for reducing discomfort associated with hemorrhoids. Physiomanna Procto marks a significant step forward, particularly in terms of rapid symptom control, ease of use, and excellent palatability, helping to promote better treatment adherence.










